Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The development of bleomycin-induced pulmonary fibrosis in mice deficient for components of the fibrinolytic system.

The American journal of pathology - 1 Jul 2000

Swaisgood C M, French E L, Noga C, Simon R H, Ploplis V A

Abstract excerpt

Acute and chronic pulmonary diseases are characterized by impaired fibrinolytic activity within the lung. To determine the role of the fibrinolytic system in regulating the pathologies associated with lung injury, we examined the effect of bleomycin, an agent that induces the development of pulmonary fibrosis, in mice deficient for plasminogen (Pg(-)(/-)), urokinase (u-PA(-)(/-)), urokinase receptor...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bleomycin
Share to Blood Coagulation Factors
Share to Fibrin

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Matrix Metalloproteinase 12

Share to Plasminogen

Share to Receptors, Urokinase Plasminogen Activator

Share to Tissue Plasminogen Activator

Share to Urokinase-Type Plasminogen Activator

Source

Open in PubMed Open full text

Identifiers

PMID: 10880388
DOI: 10.1016/S0002-9440(10)64529-4
PMCID: PMC1850221

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The development of bleomycin-induced pulmonary fibrosis in mice deficient for components of the fibrinolytic system.PMID 10880388Read ↗

Development of pulmonary fibrosis in fibrinogen-deficient mice.Semantic proximity Read ↗

Bleomycin-induced pulmonary fibrosis in fibrinogen-null mice.Semantic proximity Read ↗

Urokinase Plasminogen Activator Overexpression Reverses Established Lung Fibrosis.Semantic proximity Read ↗

Endothelial Cells Recruit Macrophages and Contribute to a Fibrotic Milieu in Bleomycin Lung InjurySemantic proximity Read ↗

MEK1/2 and ERK1/2 mediated lung endothelial injury and altered hemostasis promote diffuse alveolar hemorrhage in murine lupusSemantic proximity Read ↗

Development and disease in proteinase-deficient mice: role of the plasminogen, matrix metalloproteinase and coagulation system.Semantic proximity Read ↗

An essential role for CCAAT/enhancer binding protein beta in bleomycin-induced pulmonary fibrosis.Semantic proximity Read ↗

Cardiac Hemorrhage Precedes Hypertension-induced Fibrosis in Plasminogen Activator Inhibitor-1 Deficient MiceSemantic proximity Read ↗

Megakaryoblastic leukemia-1 is required for the development of bleomycin-induced pulmonary fibrosis.Semantic proximity Read ↗

Inducible lung-specific urokinase expression reduces fibrosis and mortality after lung injury in mice.Semantic proximity Read ↗

Lung Inflammatory Phenotype in Mice Deficient in Fibulin-2 and ADAMTS-12.Semantic proximity Read ↗

Plasminogen Activator Inhibitor-1 Protects Mice Against Cardiac Fibrosis by Inhibiting Urokinase-type Plasminogen Activator-mediated Plasminogen Activation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.