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Article

Clonal Evolution of MEK/MAPK Pathway Activating Mutations in a Metastatic Colorectal Cancer Case.

Anticancer research - 1 Nov 2019

Lehtomaki Kaisa I, Lahtinen Laura I, Rintanen Nina, Kuopio Teijo, Kholova Ivana, Makela Rami, Rantala Juha K, Kellokumpu-Lehtinen Pirkko-Liisa, Kononen Juha

Abstract excerpt

BACKGROUND/AIM: The aim of this study was to examine clonal heterogeneity, to test the utility of liquid biopsy in monitoring disease progression and to evaluate the usefulness of ex vivo drug screening in a BRAF L597Q-mutated colorectal cancer (CRC) patient developing metastases during adjuvant therapy. MATERIALS AND METHODS: Next generation sequencing (NGS) and droplet digital PCR (ddPCR) were performed in...

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PMID: 31704811
DOI: 10.21873/anticanres.13791

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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