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Article

Applicability of liquid biopsies to represent the mutational profile of tumor tissue from different cancer entities.

Oncogene - 1 Aug 2021

Liebs Sandra, Eder Theresa, Klauschen Frederick, Schütte Moritz, Yaspo Marie-Laure, Keilholz Ulrich, Tinhofer Ingeborg, Kidess-Sigal Evelyn, Braunholz Diana

Abstract excerpt

Genetic investigation of tumor heterogeneity and clonal evolution in solid cancers could be assisted by the analysis of liquid biopsies. However, tumors of various entities might release different quantities of circulating tumor cells (CTCs) and cell-free DNA (cfDNA) into the bloodstream, potentially limiting the diagnostic potential of liquid biopsy in distinct tumor histologies. Patients with advanced...

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Identifiers

PMID: 34230613
DOI: 10.1038/s41388-021-01928-w
PMCID: PMC8376638

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