Article
Machine Learning for Prioritization of Thermostabilizing Mutations for G-Protein Coupled Receptors.
Biophysical journal - 3 Dec 2019
Muk Sanychen, Ghosh Soumadwip, Achuthan Srisairam, Chen Xiaomin, Yao XiaoJie, Sandhu Manbir, Griffor Matthew C, Fennell Kimberly F, Che Ye, Shanmugasundaram Veerabahu, Qiu Xiayang, Tate Christopher G, Vaidehi Nagarajan
Abstract excerpt
Although the three-dimensional structures of G-protein coupled receptors (GPCRs), the largest superfamily of drug targets, have enabled structure-based drug design, there are no structures available for 87% of GPCRs. This is due to the stiff challenge in purifying the inherently flexible GPCRs. Identifying thermostabilized mutant GPCRs via systematic alanine scanning mutations has been a successful strategy in...
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