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Article

Identification of thermostabilizing mutations for a membrane protein whose three-dimensional structure is unknown.

Journal of computational chemistry - 5 Feb 2017

Kajiwara Yuta, Yasuda Satoshi, Takamuku Yuuki, Murata Takeshi, Kinoshita Masahiro

Abstract excerpt

We recently developed a physics-based method for identifying thermostabilizing mutations of a membrane protein. The method uses a free-energy function F where the importance of translational entropy of hydrocarbon groups within the lipid bilayer is emphasized. All of the possible mutations can rapidly be examined. The method was illustrated for the adenosine A2a receptor (A2a R) whose three-dimensional (3D)...

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Identifiers

PMID: 27862099
DOI: 10.1002/jcc.24673

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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