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IMPROvER: the Integral Membrane Protein Stability Selector.

Scientific reports - 16 Sept 2020

Harborne Steven P D, Strauss Jannik, Boakes Jessica C, Wright Danielle L, Henderson James G, Boivineau Jacques, Jaakola Veli-Pekka, Goldman Adrian

Abstract excerpt

Identifying stabilising variants of membrane protein targets is often required for structure determination. Our new computational pipeline, the Integral Membrane Protein Stability Selector (IMPROvER) provides a rational approach to variant selection by employing three independent approaches: deep-sequence, model-based and data-driven. In silico tests using known stability data, and in vitro tests using three...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32938971
DOI: 10.1038/s41598-020-71744-x
PMCID: PMC7495477

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