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Article

Predicting changes in protein thermostability brought about by single- or multi-site mutations.

BMC bioinformatics - 2 Jul 2010

Tian Jian, Wu Ningfeng, Chu Xiaoyu, Fan Yunliu

Abstract excerpt

BACKGROUND: An important aspect of protein design is the ability to predict changes in protein thermostability arising from single- or multi-site mutations. Protein thermostability is reflected in the change in free energy (DeltaDeltaG) of thermal denaturation. RESULTS: We have developed predictive software, Prethermut, based on machine learning methods, to predict the effect of single- or multi-site mutations on...

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Identifiers

PMID: 20598148
DOI: 10.1186/1471-2105-11-370
PMCID: PMC2906492

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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