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Article

Immune Gene Expression Is Associated with Genomic Aberrations in Breast Cancer

20 Apr 2017

Abstract excerpt

Abstract The presence of tumor-infiltrating lymphocytes (TIL) is a favorable prognostic factor in breast cancer, but what drives immune infiltration remains unknown. Here we examine if clonal heterogeneity, total mutation load, neoantigen load, copy number variations (CNV), gene- or pathway-level somatic mutations, or germline polymorphisms (SNP) are associated with immune metagene expression in breast cancer...

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PMID: 28428277
DOI: 10.1158/0008-5472.can-16-3478

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