Article
HDAC3 functions as a positive regulator in Notch signal transduction.
Nucleic acids research - 17 Apr 2020
Ferrante Francesca, Giaimo Benedetto Daniele, Bartkuhn Marek, Zimmermann Tobias, Close Viola, Mertens Daniel, Nist Andrea, Stiewe Thorsten, Meier-Soelch Johanna, Kracht Michael, Just Steffen, Klöble Patricia, Oswald Franz, Borggrefe Tilman
Abstract excerpt
Aberrant Notch signaling plays a pivotal role in T-cell acute lymphoblastic leukemia (T-ALL) and chronic lymphocytic leukemia (CLL). Amplitude and duration of the Notch response is controlled by ubiquitin-dependent proteasomal degradation of the Notch1 intracellular domain (NICD1), a hallmark of the leukemogenic process. Here, we show that HDAC3 controls NICD1 acetylation levels directly affecting NICD1 protein...
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