Article
Loss of the Notch effector RBPJ promotes tumorigenesis.
The Journal of experimental medicine - 12 Jan 2015
Kulic Iva, Robertson Gordon, Chang Linda, Baker Jennifer H E, Lockwood William W, Mok Winnie, Fuller Megan, Fournier Michèle, Wong Nelson, Chou Vennie, Robinson Mark D, Chun Hye-Jung, Gilks Blake, Kempkes Bettina, Thomson Thomas A, Hirst Martin, Minchinton Andrew I, Lam Wan L, Jones Steven, Marra Marco, Karsan Aly
Abstract excerpt
Aberrant Notch activity is oncogenic in several malignancies, but it is unclear how expression or function of downstream elements in the Notch pathway affects tumor growth. Transcriptional regulation by Notch is dependent on interaction with the DNA-binding transcriptional repressor, RBPJ, and consequent derepression or activation of associated gene promoters. We show here that RBPJ is frequently depleted in...
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