Article
The role of clonal haematopoiesis in cardiovascular diseases: epidemiology and experimental studies.
Journal of internal medicine - 1 Nov 2020
Min K D, Kour A, Sano S, Walsh K
Abstract excerpt
Clonal haematopoiesis results from acquired mutations in haematopoietic stem and progenitor cells (HSPCs). These mutations can confer the HSPC with a competitive advantage, leading to their clonal expansion within the limiting bone marrow niche. This process is often insufficient to produce a haematologic malignancy; however, the expanding HSPC clones increasingly give rise to progeny leucocytes whose phenotypes...
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