Article
The -675 4G/5G PAI-1 polymorphism confers genetic susceptibility to systemic lupus erythematosus, its clinical manifestations, and comorbidities in Mexican-Mestizo population.
Autoimmunity - 1 Mar 2020
Anaya-Macias B U, De la Cruz-Mosso U, Palafox-Sánchez C A, Parra-Rojas I, Martínez-Bonilla G, González-López L, Gámez-Nava J I, Pérez-Guerrero E E, Barrientos-Avalos S L, Muñoz-Valle J F
Abstract excerpt
Systemic lupus erythematosus (SLE) involves a broad range of factors that contribute to the development of the disease and its comorbidities. Genetic predisposition influences the development of SLE, and the -675 4G/5G PAI-1 polymorphism has been associated with several pathologies with a chronic inflammatory component. Our objective was to investigate the genetic association between the -675 4G/5G PAI-1...
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