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Article

PAI-1 mRNA expression and plasma level in rheumatoid arthritis: relationship with 4G/5G PAI-1 polymorphism.

Rheumatology international - 1 Dec 2012

Muñoz-Valle José Francisco, Ruiz-Quezada Sandra Luz, Oregón-Romero Edith, Navarro-Hernández Rosa Elena, Castañeda-Saucedo Eduardo, De la Cruz-Mosso Ulises, Illades-Aguiar Berenice, Leyva-Vázquez Marco Antonio, Castro-Alarcón Natividad, Parra-Rojas Isela

Abstract excerpt

Rheumatoid arthritis (RA) is a chronic inflammatory disease affecting the synovial membrane, cartilage and bone. PAI-1 is a key regulator of the fibrinolytic system through which plasminogen is converted to plasmin. The plasmin activates the matrix metalloproteinase system, which is closely relat...

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PMID: 22200807
DOI: 10.1007/s00296-011-2279-y

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22200807-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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