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Article

The molecular functions of hepatocyte nuclear factors - In and beyond the liver.

Journal of hepatology - 1 May 2018

Lau Hwee Hui, Ng Natasha Hui Jin, Loo Larry Sai Weng, Jasmen Joanita Binte, Teo Adrian Kee Keong

Abstract excerpt

The hepatocyte nuclear factors (HNFs) namely HNF1α/β, FOXA1/2/3, HNF4α/γ and ONECUT1/2 are expressed in a variety of tissues and organs, including the liver, pancreas and kidney. The spatial and temporal manner of HNF expression regulates embryonic development and subsequently the development of multiple tissues during adulthood. Though the HNFs were initially identified individually based on their roles in the...

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Gene Regulatory Networks
Kidney
Liver
Diabetes Mellitus, Type 2
Gene Expression Regulation, Developmental

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Metabolic Networks and Pathways

Tissue Distribution

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Identifiers

PMID: 29175243
DOI: 10.1016/j.jhep.2017.11.026

Genes

FOXA1
ONECUT1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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