Paternal Contributions to Offspring Health: Role of Sperm Small RNAs in Intergenerational Transmission of Epigenetic Information

Abstract excerpt

The most fundamental process for the perpetuation of a species is the transfer of information from parent to offspring. Although genomic DNA contributes to the majority of the inheritance, it is now clear that epigenetic information -information beyond the underlying DNA sequence - is also passed on to future generations. However, the mechanism and extent of such inheritance are not well-understood. Here, I...

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