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Epididymal acquired sperm microRNAs modify post-fertilization embryonic gene expression

1 Sept 2024

Abstract excerpt

Sperm small RNAs have emerged as important non-genetic contributors to embryogenesis and offspring health. A subset of sperm small RNAs is thought to be acquired during epididymal transit. However, the identity of the specific small RNAs transferred remains unclear. Here, we employ Cre/Lox genetics to generate germline- and epididymal-specific Dgcr8 knockout (KO) mice to investigate the dynamics of sperm...

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PMID: 39226174
DOI: 10.1016/j.celrep.2024.114698

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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