Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Future in the past: paternal reprogramming of offspring phenotype and the epigenetic mechanisms.

Archives of toxicology - 1 Jun 2024

Wu Di, Zhang Kejia, Guan Kaifeng, Khan Faheem Ahmed, Pandupuspitasari Nuruliarizki Shinta, Negara Windu, Sun Fei, Huang Chunjie

Abstract excerpt

That certain preconceptual paternal exposures reprogram the developmental phenotypic plasticity in future generation(s) has conceptualized the "paternal programming of offspring health" hypothesis. This transgenerational effect is transmitted primarily through sperm epigenetic mechanisms-DNA methylation, non-coding RNAs (ncRNAs) and associated RNA modifications, and histone modifications-and potentially through...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA Methylation
Share to Epigenesis, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Paternal Inheritance

Share to Phenotype

Share to RNA, Untranslated

Share to Spermatozoa

Source

Identifiers

PMID: 38460001
DOI: 10.1007/s00204-024-03713-6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Future in the past: paternal reprogramming of offspring phenotype and the epigenetic mechanisms.PMID 38460001Read ↗

Environmental and Genetic Traffic in the Journey from Sperm to Offspring.Semantic proximity Read ↗

Epigenetic effects of paternal environmental exposures and experiences on offspring phenotypes.Semantic proximity Read ↗

Sperm epigenetics and influence of environmental factorsSemantic proximity Read ↗

Emerging evidence that the mammalian sperm epigenome serves as a template for embryo developmentSemantic proximity Read ↗

A Decade of Exploring the Mammalian Sperm Epigenome: Paternal Epigenetic and Transgenerational InheritanceSemantic proximity Read ↗

Parental genetic effects on the offspring's phenotype without transmission of the gene itself-pathophysiology and clinical evidence.Semantic proximity Read ↗

Epigenetic Mechanisms of Paternal Stress in Offspring Development and DiseasesSemantic proximity Read ↗

A paternal environmental legacy: Evidence for epigenetic inheritance through the male germ lineSemantic proximity Read ↗

Paternal Contributions to Offspring Health: Role of Sperm Small RNAs in Intergenerational Transmission of Epigenetic InformationSemantic proximity Read ↗

Germline epigenetic inheritance: Challenges and opportunities for linking human paternal experience with offspring biology and healthSemantic proximity Read ↗

Epigenetics as a Driver of Developmental Origins of Health and Disease: Did We Forget the Fathers?Semantic proximity Read ↗

Paternal impact on the developmental programming of sexual dimorphismSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.