Article
Alterations in sperm RNAs persist after alcohol cessation and correlate with epididymal mitochondrial dysfunction
3 Dec 2023
Abstract excerpt
BACKGROUND: Chronic preconception paternal alcohol use adversely modifies the sperm epigenome, inducing fetoplacental and craniofacial growth defects in the offspring of exposed males. A crucial outstanding question in the field of paternal epigenetic inheritance concerns the resilience of the male germline and its capacity to recover and correct sperm-inherited epigenetic errors after stressor withdrawal....
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