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Article

The effect of surface roughness on RAW 264.7 macrophage phenotype.

Journal of biomedical materials research. Part A - 1 Sept 2013

Barth Katrin A, Waterfield J Douglas, Brunette Donald M

Abstract excerpt

Monocyte-derived cells, including macrophages and foreign body giant cells, can determine the performance of implanted devices. Upon contact with biomaterials, macrophages can be activated into a classic inflammatory (M1) or wound-healing (M2) phenotype. Previously, we showed that high macrophage density on rough SLA implants was associated with early bone formation. This study examined a possible mechanism,...

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Source

Identifiers

PMID: 23427077
DOI: 10.1002/jbm.a.34562

Genes

SLA
NOS2
MIP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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