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Aseptic Loosening in Total Hip Arthroplasty: Pathophysiology, Biomarkers, and Preventive Treatment Strategies

2025-07-29

Abstract excerpt

Aseptic loosening (AL) represents the leading cause of long-term failure in total joint arthroplasty, often necessitating revision surgery. This review explores the complex mechanisms underlying AL, which involve a multifaceted interaction between the implanted biomaterials and the host immune response. We outline the key inflammatory mechanisms triggered by wear debris from polyethylene, polymethylmethacrylate, m...

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Literature Corpus work
94167df6-b029-595e-bd84-f428be2e2ada
DOI
10.20944/preprints202507.2365.v1
Open publication

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Aseptic Loosening in Total Hip Arthroplasty: Pathophysiology, Biomarkers, and Preventive Treatment StrategiesDOI 10.20944/preprints202507.2365.v1
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