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Article

Surveillance Endoscopy in the Management of Hereditary Diffuse Gastric Cancer Syndrome.

Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association - 1 Jan 2021

Friedman Madeline, Adar Tomer, Patel Devanshi, Lauwers Gregory Y, Yoon Sam S, Mullen John T, Chung Daniel C

Abstract excerpt

Hereditary diffuse gastric cancer (HDGC) syndrome results from a germline CDH1 mutation, and microscopic foci of signet-ring carcinoma cells (SRCC) are present in nearly all gastrectomy specimens.1 The lifetime risk of invasive gastric cancer (GC) has been thought to be 70%,2 but recent data have suggested a lower risk of 37%.3 Prophylactic total gastrectomy is considered the standard of care, but many patients...

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Source

Identifiers

PMID: 31678201
DOI: 10.1016/j.cgh.2019.10.033

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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