Article
The Cancer Genome Atlas Comprehensive Molecular Characterization of Renal Cell Carcinoma.
Cell reports - 3 Apr 2018
Ricketts Christopher J, De Cubas Aguirre A, Fan Huihui, Smith Christof C, Lang Martin, Reznik Ed, Bowlby Reanne, Gibb Ewan A, Akbani Rehan, Beroukhim Rameen, Bottaro Donald P, Choueiri Toni K, Gibbs Richard A, Godwin Andrew K, Haake Scott, Hakimi A Ari, Henske Elizabeth P, Hsieh James J, Ho Thai H, Kanchi Rupa S, Krishnan Bhavani, Kwiatkowski David J, Liu Wenbin, Merino Maria J, Mills Gordon B, Myers Jerome, Nickerson Michael L, Reuter Victor E, Schmidt Laura S, Shelley C Simon, Shen Hui, Shuch Brian, Signoretti Sabina, Srinivasan Ramaprasad, Tamboli Pheroze, Thomas George, Vincent Benjamin G, Vocke Cathy D, Wheeler David A, Yang Lixing, Kim William Y, Robertson A Gordon, Spellman Paul T, Rathmell W Kimryn, Linehan W Marston
Abstract excerpt
Renal cell carcinoma (RCC) is not a single disease, but several histologically defined cancers with different genetic drivers, clinical courses, and therapeutic responses. The current study evaluated 843 RCC from the three major histologic subtypes, including 488 clear cell RCC, 274 papillary RCC, and 81 chromophobe RCC. Comprehensive genomic and phenotypic analysis of the RCC subtypes reveals distinctive...
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