Article
Use of Phenotypically Poor Metabolizer Individual Donor Human Liver Microsomes To Identify Selective Substrates of UGT2B10.
Drug metabolism and disposition: the biological fate of chemicals - 1 Mar 2020
Milani Nicolo, Qiu NaHong, Molitor Birgit, Badée Justine, Cruciani Gabriele, Fowler Stephen
Abstract excerpt
UDP-glucuronosyltransferase (UGT)1A4 and UGT2B10 are the human UGT isoforms most frequently involved in N-glucuronidation of drugs. UGT2B10 exhibits higher affinity than UGT1A4 for numerous substrates, making it potentially the more important enzyme for metabolism of these compounds in vivo. Clinically relevant UGT2B10 polymorphisms, including a null activity splice site mutation common in African populations,...
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