Article
Quantitative in vitro phenotyping and prediction of drug interaction potential of CYP2B6 substrates as victims.
Xenobiotica; the fate of foreign compounds in biological systems - 1 Jul 2018
Palacharla Raghava Choudary, Nirogi Ramakrishna, Uthukam Venkatesham, Manoharan Arunkumar, Ponnamaneni Ranjith Kumar, Kalaikadhiban Ilayaraja
Abstract excerpt
1. Determination of fm, CYP for a compound is critical to assess the potential risk of a drug candidate as a victim of DDI. Several compounds are identified as CYP2B6 substrates, but the fm, CYP2B6 values are not determined quantitatively. 2. Two methods of reaction phenotyping, the chemical inhibition method and metabolism in rCYP enzymes, were used to determine the relative contributions of the enzymes....
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