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Article

Shaping the heart: Structural and functional maturation of iPSC-cardiomyocytes in 3D-micro-scaffolds.

Biomaterials - 1 Jan 2020

Silbernagel Nicole, Körner Arlene, Balitzki Jakob, Jaggy Mona, Bertels Sarah, Richter Benjamin, Hippler Marc, Hellwig Andrea, Hecker Markus, Bastmeyer Martin, Ullrich Nina D

Abstract excerpt

Cardiomyocytes derived from induced pluripotent stem cells (iPSC-CMs) represent the best cell source for cardiac regenerative purposes but retain an immature phenotype after differentiation with significant limitations compared to adult cardiomyocytes. Apart from an incomplete cardiomyocyte-specific structure and microarchitecture, cells show at the level of Ca2+ signaling only slow Ca2+ release and reuptake...

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Identifiers

PMID: 31670034
DOI: 10.1016/j.biomaterials.2019.119551

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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