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Article

Slow but Steady Wins the Race: Dissimilarities among New Dual Inhibitors of the Wild-Type and the V27A Mutant M2 Channels of Influenza A Virus.

Journal of medicinal chemistry - 11 May 2017

Barniol-Xicota Marta, Gazzarrini Sabrina, Torres Eva, Hu Yanmei, Wang Jun, Naesens Lieve, Moroni Anna, Vázquez Santiago

Abstract excerpt

New insights on the amantadine resistance mechanism of the V27A mutant were obtained through the study of novel, easily accessible 4-(1- and 2-adamantyl)piperidines, identified as dual binders of the wild-type and V27A mutant M2 channels of influenza A virus. Their antiviral activity and channel blocking ability were determined using cell-based assays and two-electrode voltage clamp (TEVC) technique on M2...

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Identifiers

PMID: 28418242
DOI: 10.1021/acs.jmedchem.6b01758
PMCID: PMC5972026

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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