Article
Moringa oleifera leaf polysaccharides exert anti-lung cancer effects upon targeting TLR4 to reverse the tumor-associated macrophage phenotype and promote T-cell infiltration.
Food & function - 22 May 2023
Wang Shukai, Hu Qian, Chang Zihao, Liu Yuqi, Gao Ye, Luo Xiaowei, Zhou Lipeng, Chen Yinxin, Cui Yitong, Wang Zhaohui, Wang Baojin, Huang Ya, Liu Yue, Liu Runping, Zhang Lanzhen
Abstract excerpt
Tumor-associated macrophages (TAMs) participate in tumorigenesis, growth, invasion as well as metastasis by facilitating an immunosuppressive tumor microenvironment. Reversing the pro-tumoral M2 phenotype of TAMs has become a hot spot in advancing cancer immunotherapy. In the current study, the content of Moringa oleifera leaf polysaccharides (MOLP) was determined and characterized, along with the anti-cancer...
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