The Role of Innate Priming in Modifying Tumor-associated Macrophage Phenotype.

Abstract excerpt

Tumor-associated macrophages (TAMs) are innate immune cells that exert far reaching influence over the tumor microenvironment (TME). Depending on cues within the local environment, TAMs may promote tumor angiogenesis, cancer cell invasion and immunosuppression, or, alternatively, inhibit tumor progression via neoantigen presentation, tumoricidal reactive oxygen species generation and pro-inflammatory cytokine...

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• Epigenesis, Genetic
• Immunity, Innate
• Neoplasms
• Phenotype
• Tumor-Associated Macrophages