Article

MFNG promotes endothelial-to-mesenchymal transition mediated by the Notch signalling pathway during heart valve development

2023-12-20

Abstract excerpt

<title>Abstract</title> <p>A fundamental event in the formation of heart valves involves the transformation of endocardial cells within the outflow tract (OFT) and atrioventricular canal (AVC) cushions through a process known as endothelial-to-mesenchymal transition (EndMT). Aberrant EndMT is a primary cause of congenital valvular malformations. Manic Fringe (MFNG) has been previously associated with cardiovascul...

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Literature Corpus work: 9d06c328-ce22-5f23-9d05-6f3dc7eb98d4
DOI: 10.21203/rs.3.rs-3652968/v1

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