Article
Detection of ESR1 Mutations in Single Circulating Tumor Cells on Estrogen Deprivation Therapy but Not in Primary Tumors from Metastatic Luminal Breast Cancer Patients.
The Journal of molecular diagnostics : JMD - 1 Jan 2020
Franken André, Honisch Ellen, Reinhardt Florian, Meier-Stiegen Franziska, Yang Liwen, Jaschinski Sandra, Esposito Irene, Alberter Barbara, Polzer Bernhard, Huebner Hanna, Fasching Peter A, Pancholi Sunil, Martin Lesley-Ann, Ruckhaeberle Eugen, Schochter Fabienne, Tzschaschel Marie, Hartkopf Andreas D, Mueller Volkmar, Niederacher Dieter, Fehm Tanja, Neubauer Hans
Abstract excerpt
Mutations in the ligand-binding domain (LBD) of the ESR1 gene result in resistance to estrogen deprivation therapy (EDT) in breast cancer. Their detection might enable optimization of therapy strategies. However, the predictive utility of the primary tumor (PT) is limited, and obtaining serial biopsies of metastatic lesions is challenging. To underline their application as a liquid biopsy, single circulating...
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