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Detection of ESR1 mutations in plasma and tumors from metastatic breast cancer patients using next-generation sequencing.

Breast cancer research and treatment - 1 Jun 2017

Yanagawa Takehiro, Kagara Naofumi, Miyake Tomohiro, Tanei Tomonori, Naoi Yasuto, Shimoda Masafumi, Shimazu Kenzo, Kim Seung Jin, Noguchi Shinzaburo

Abstract excerpt

PURPOSE: Liquid biopsy using digital PCR (dPCR) has been widely used for the screening of ESR1 mutations, since they are frequently identified in the hotspot. However, dPCR is limited to the known mutations. Therefore, we aimed to analyze the utility of next-generation sequencing (NGS) to discover novel ESR1 mutations. METHODS: Whole exon sequencing of the ESR1 gene using NGS was performed in 16 primary and 47...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 28283903
DOI: 10.1007/s10549-017-4190-z

Genes

ESR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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