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Article

Detection of Activating Estrogen Receptor Gene (ESR1) Mutations in Single Circulating Tumor Cells.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Oct 2017

Paolillo Carmela, Mu Zhaomei, Rossi Giovanna, Schiewer Matthew J, Nguyen Thomas, Austin Laura, Capoluongo Ettore, Knudsen Karen, Cristofanilli Massimo, Fortina Paolo

Abstract excerpt

Purpose: Early detection is essential for treatment plans before onset of metastatic disease. Our purpose was to demonstrate feasibility to detect and monitor estrogen receptor 1 (ESR1) gene mutations at the single circulating tumor cell (CTC) level in metastatic breast cancer (MBC).Experimental Design: We used a CTC molecular characterization approach to investigate heterogeneity of 14 hotspot mutations in ESR1...

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Identifiers

PMID: 28679775
DOI: 10.1158/1078-0432.CCR-17-1173
PMCID: PMC5641250

Genes

ESR1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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