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Article

ESR1 Mutations in Circulating Plasma Tumor DNA from Metastatic Breast Cancer Patients

10 Aug 2015

Abstract excerpt

PURPOSE: Mutations in the estrogen receptor (ER)α gene, ESR1, have been identified in breast cancer metastases after progression on endocrine therapies. Because of limitations of metastatic biopsies, the reported frequency of ESR1 mutations may be underestimated. Here, we show a high frequency of ESR1 mutations using circulating plasma tumor DNA (ptDNA) from patients with metastatic breast cancer. EXPERIMENTAL...

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Identifiers

PMID: 26261103
DOI: 10.1158/1078-0432.ccr-15-0943

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