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Article

ESR1 mutations: Moving towards guiding treatment decision-making in metastatic breast cancer patients.

Cancer treatment reviews - 1 Jan 2017

Angus Lindsay, Beije Nick, Jager Agnes, Martens John W M, Sleijfer Stefan

Abstract excerpt

Mutations in the gene coding for the estrogen receptor (ER), ESR1, have been associated with acquired endocrine resistance in patients with ER-positive metastatic breast cancer (MBC). Functional studies revealed that these ESR1 mutations lead to constitutive activity of the ER, meaning that the receptor is active in absence of its ligand estrogen, conferring resistance against several endocrine agents. While...

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Identifiers

PMID: 27886589
DOI: 10.1016/j.ctrv.2016.11.001

Genes

ESR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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