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Article

Estrogen receptor mutations and splice variants determined in liquid biopsies from metastatic breast cancer patients.

Molecular oncology - 1 Jan 2018

Beije Nick, Sieuwerts Anieta M, Kraan Jaco, Van Ngoc M, Onstenk Wendy, Vitale Silvia R, van der Vlugt-Daane Michelle, Dirix Luc Y, Brouwer Anja, Hamberg Paul, de Jongh Felix E, Jager Agnes, Seynaeve Caroline M, Jansen Maurice P H M, Foekens John A, Martens John W M, Sleijfer Stefan

Abstract excerpt

Mutations and splice variants in the estrogen receptor (ER) gene, ESR1, may yield endocrine resistance in metastatic breast cancer (MBC) patients. These putative endocrine resistance markers are likely to emerge during treatment, and therefore, its detection in liquid biopsies, such as circulating tumor cells (CTCs) and cell-free DNA (cfDNA), is of great interest. This research aimed to determine whether ESR1...

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Source

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Identifiers

PMID: 29063679
DOI: 10.1002/1878-0261.12147
PMCID: PMC5748489

Genes

ESR1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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