Article
Noninvasive detection of activating estrogen receptor 1 (ESR1) mutations in estrogen receptor-positive metastatic breast cancer.
Clinical chemistry - 1 Jul 2015
Guttery David S, Page Karen, Hills Allison, Woodley Laura, Marchese Stephanie D, Rghebi Basma, Hastings Robert K, Luo Jinli, Pringle J Howard, Stebbing Justin, Coombes R Charles, Ali Simak, Shaw Jacqueline A
Abstract excerpt
BACKGROUND: Activating mutations in the estrogen receptor 1 (ESR1) gene are acquired on treatment and can drive resistance to endocrine therapy. Because of the spatial and temporal limitations of needle core biopsies, our goal was to develop a highly sensitive, less invasive method of detecting activating ESR1 mutations via circulating cell-free DNA (cfDNA) and tumor cells as a "liquid biopsy." METHODS: We...
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