Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Evolution and Impact of Subclonal Mutations in Papillary Thyroid Cancer.

American journal of human genetics - 7 Nov 2019

Masoodi Tariq, Siraj Abdul K, Siraj Sarah, Azam Saud, Qadri Zeeshan, Parvathareddy Sandeep K, Al-Sobhi Saif S, AlDawish Mohammed, Alkuraya Fowzan S, Al-Kuraya Khawla S

Abstract excerpt

Unlike many cancers, the pattern of tumor evolution in papillary thyroid cancer (PTC) and its potential role in relapse have not been elucidated. In this study, multi-region whole-exome sequencing (WES) was performed on early-stage PTC tumors (n = 257 tumor regions) from 79 individuals, including 17 who had developed relapse, to understand the temporal and spatial framework within which subclonal mutations...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adolescent
Share to Cancer Genomics and Diagnostics

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Evolution, Molecular

Share to Exome Sequencing

Share to Mutation

Share to Neoplasm Recurrence, Local

Share to Thyroid Cancer, Papillary

Source

Open in PubMed Open full text

Identifiers

PMID: 31668701
DOI: 10.1016/j.ajhg.2019.09.026
PMCID: PMC6849094

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Evolution and Impact of Subclonal Mutations in Papillary Thyroid Cancer.PMID 31668701Read ↗

Shifting patterns of genomic variation in the somatic evolution of papillary thyroid carcinoma.Semantic proximity Read ↗

Intratumor heterogeneity and clonal evolution in an aggressive papillary thyroid cancer and matched metastases.Semantic proximity Read ↗

Genomic Profiling of Thyroid Cancer Reveals a Role for Thyroglobulin in Metastasis.Semantic proximity Read ↗

Whole-Exome Sequencing of Matched Primary and Metastatic Papillary Thyroid Cancer.Semantic proximity Read ↗

Most multifocal papillary thyroid carcinomas acquire genetic and morphotype diversity through subclonal evolution following the intra-glandular spread of the initial neoplastic clone.Semantic proximity Read ↗

Early evolutionary divergence between papillary and anaplastic thyroid cancers.Semantic proximity Read ↗

Comprehensive genomic profiling of infiltrative follicular variant of papillary thyroid carcinoma.Semantic proximity Read ↗

Genomic landscape of metastatic papillary thyroid carcinoma and novel biomarkers for predicting distant metastasis.Semantic proximity Read ↗

Deconvolving mutation and selection reveals stage-specific drivers of thyroid cancerSemantic proximity Read ↗

Clonality analysis of multifocal papillary thyroid carcinoma by using genetic profilesSemantic proximity Read ↗

Genomic evolution and the impact of SLIT2 mutation in relapsed intrahepatic cholangiocarcinoma.Semantic proximity Read ↗

The genomic architectures of tumour-adjacent tissues, plasma and saliva reveal evolutionary underpinnings of relapse in head and neck squamous cell carcinoma.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.