Article
Early evolutionary divergence between papillary and anaplastic thyroid cancers.
Annals of oncology : official journal of the European Society for Medical Oncology - 1 Jun 2018
Capdevila J, Mayor R, Mancuso F M, Iglesias C, Caratù G, Matos I, Zafón C, Hernando J, Petit A, Nuciforo P, Cameselle-Teijeiro J M, Álvarez C, Recio J A, Tabernero J, Matias-Guiu X, Vivancos A, Seoane J
Abstract excerpt
Background: Papillary thyroid cancer (PTC) is the most common thyroid carcinoma and exhibits an almost uniformly good prognosis, while anaplastic thyroid cancer (ATC) is less frequent and is one of the most aggressive cancers usually resistant to conventional treatment. Current hypothesis posits that ATC derives from PTC through the progressive acquisition of a discrete number of genomic alterations and implies...
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