Article
Shifting patterns of genomic variation in the somatic evolution of papillary thyroid carcinoma.
BMC cancer - 18 Aug 2016
Rubinstein Jill C, Brown Taylor C, Christison-Lagay Emily R, Zhang Yawei, Kunstman John W, Juhlin C Christofer, Nelson-Williams Carol, Goh Gerald, Quinn Courtney E, Callender Glenda G, Udelsman Robert, Lifton Richard P, Korah Reju, Carling Tobias
Abstract excerpt
BACKGROUND: Cancer is increasingly understood to arise in the context of dynamically evolving genomes with continuously generated variants subject to selective pressures. Diverse mutations have been identified in papillary thyroid carcinoma (PTC), but unifying theories underlying genomic change are lacking. Applying a framework of somatic evolution, we sought to broaden understanding of the PTC genome through...
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