Article

Deconvolving mutation and selection reveals stage-specific drivers of thyroid cancer

2025-10-08

Abstract excerpt

<h4>Objective</h4> Mutational profiles of primary and metastatic thyroid cancer (THCA) have been examined by comparison of somatic mutation prevalences in the two stages, using P values to identify significant differences. However, prevalences and P values for mutations do not directly quantify the cancer effects of somatic variants. <h4>Methods</h4> We calculated cancer effect sizes accounting for substantia...

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Literature Corpus work: 8e67b8d4-a2a4-53ab-9c89-e49af7a758b7
DOI: 10.1101/2025.10.08.681166

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