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Article

Phenotypic and genotypic landscape of PROKR2 in neuroendocrine disorders.

Frontiers in endocrinology - 1 Jan 2023

Martinez-Mayer Julian, Perez-Millan Maria Ines

Abstract excerpt

Prokineticin receptor 2 (PROKR2) encodes for a G-protein-coupled receptor that can bind PROK1 and PROK2. Mice lacking Prokr2 have been shown to present abnormal olfactory bulb formation as well as defects in GnRH neuron migration. Patients carrying mutations in PROKR2 typically present hypogonadotropic hypogonadism, anosmia/hyposmia or Kallmann Syndrome. More recently variants in PROKR2 have been linked to...

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Identifiers

PMID: 36843573
DOI: 10.3389/fendo.2023.1132787
PMCID: PMC9945519

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