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Article

Cell cycle arrest through indirect transcriptional repression by p53: I have a DREAM

10 Nov 2017

Abstract excerpt

Activation of the p53 tumor suppressor can lead to cell cycle arrest. The key mechanism of p53-mediated arrest is transcriptional downregulation of many cell cycle genes. In recent years it has become evident that p53-dependent repression is controlled by the p53–p21–DREAM–E2F/CHR pathway (p53–DREAM pathway). DREAM is a transcriptional repressor that binds to E2F or CHR promoter sites. Gene regulation and...

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PMID: 29125603
DOI: 10.1038/cdd.2017.172

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Cell cycle arrest through indirect transcriptional repression by p53: I have a DREAMPMID 29125603Read ↗

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