Article
Selective YAP/TAZ inhibition in fibroblasts via dopamine receptor D1 agonism reverses fibrosis.
Science translational medicine - 30 Oct 2019
Haak Andrew J, Kostallari Enis, Sicard Delphine, Ligresti Giovanni, Choi Kyoung Moo, Caporarello Nunzia, Jones Dakota L, Tan Qi, Meridew Jeffrey, Diaz Espinosa Ana M, Aravamudhan Aja, Maiers Jessica L, Britt Rodney D, Roden Anja C, Pabelick Christina M, Prakash Y S, Nouraie Seyed Mehdi, Li Xiaoyun, Zhang Yingze, Kass Daniel J, Lagares David, Tager Andrew M, Varelas Xaralabos, Shah Vijay H, Tschumperlin Daniel J
Abstract excerpt
Tissue fibrosis is characterized by uncontrolled deposition and diminished clearance of fibrous connective tissue proteins, ultimately leading to organ scarring. Yes-associated protein (YAP) and transcriptional coactivator with PDZ-binding motif (TAZ) have recently emerged as pivotal drivers of mesenchymal cell activation in human fibrosis. Therapeutic strategies inhibiting YAP and TAZ have been hindered by the...
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