Article

PCLAF-DREAM Drives Alveolar Cell Plasticity for Lung Regeneration

2022-10-11

Abstract excerpt

Spatiotemporal control of stem and progenitor cells is essential for lung regeneration, the failure of which leads to lung disease. However, the mechanism of alveolar cell plasticity during regeneration remains elusive. We previously found that PCLAF remodels the DREAM complex for cell cycle re-entry. PCLAF expression is specifically enriched in proliferating lung progenitor cells, along with the DREAM target gene...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 8b973d1f-71d9-54ee-8056-9806d2e7db18
DOI: 10.1101/2022.10.11.511761

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

PCLAF-DREAM Drives Alveolar Cell Plasticity for Lung RegenerationDOI 10.1101/2022.10.11.511761Read

PCLAF-DREAM drives alveolar cell plasticity for lung regenerationSemantic proximity Read

Abnormal respiratory progenitors in fibrotic lung injurySemantic proximity Read

Longitudinal single cell transcriptomics reveals Krt8+ alveolar epithelial progenitors in lung regenerationSemantic proximity Read

Shared epithelial pathways to lung repair and disease.Semantic proximity Read

Regeneration-Associated Transitional State Cells in Pulmonary FibrosisSemantic proximity Read

Airway Basal Cells show a dedifferentiated KRT17 <sup>high</sup> Phenotype and promote Fibrosis in Idiopathic Pulmonary FibrosisSemantic proximity Read

Identification a novel subset of alveolar type 2 cells expanding following pneumonectomy and enriched in PD-L1Semantic proximity Read

AP-1 mediated chromatin changes govern alveolar type 2 cell transition in lung injury-repairSemantic proximity Read

TRβ activation confers AT2-to-AT1 cell differentiation and anti-fibrosis during lung repair via KLF2 and CEBPASemantic proximity Read

Alveolar epithelial cell plasticity and injury memory in human pulmonary fibrosisSemantic proximity Read

Targeting CEBPA to restore cellular identity and tissue homeostasis in pulmonary fibrosisSemantic proximity Read

Cellular plasticity and regenerative mechanisms in the lung.Semantic proximity Read