Article

Role of lung ornithine aminotransferase in Idiopathic Pulmonary Fibrosis: regulation of mitochondrial ROS generation and TGF-β1 activity

2023-09-27

Abstract excerpt

<title>Abstract</title>Idiopathic pulmonary fibrosis (IPF) exhibits aberrant lung remodeling that is characterized by excessive accumulation of extracellular matrix (ECM) proteins. In a previous study, we found that levels of ornithine aminotransferase (OAT), a principal enzyme of the proline metabolic pathway, were elevated in the lungs of patients with IPF. However, the precise role played by OAT in IPF patho...

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Literature Corpus work: d2e5a3de-1182-59e4-b393-9fc852b179b8
DOI: 10.21203/rs.3.rs-3304833/v1

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