Allele-specific DNA methylation reinforces PEAR1 enhancer activity.

doi:10.1182/blood-2015-11-682153

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Article

Allele-specific DNA methylation reinforces PEAR1 enhancer activity.

Blood - 18 Aug 2016

Izzi Benedetta, Pistoni Mariaelena, Cludts Katrien, Akkor Pinar, Lambrechts Diether, Verfaillie Catherine, Verhamme Peter, Freson Kathleen, Hoylaerts Marc F

Abstract excerpt

Genetic variation in the PEAR1 locus is linked to platelet reactivity and cardiovascular disease. The major G allele of rs12041331, an intronic cytosine guanine dinucleotide-single-nucleotide polymorphism (CpG-SNP), is associated with higher PEAR1 expression in platelets and endothelial cells than the minor A allele. The molecular mechanism underlying this difference remains elusive. We have characterized the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 27313330
DOI: 10.1182/blood-2015-11-682153

Genes

PEAR1
CTCF

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