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Article

Caveolin-1 rs4730751 single-nucleotide polymorphism may not influence kidney transplant allograft survival.

Scientific reports - 29 Oct 2019

Maanaoui Mehdi, Lenain Rémi, Hamroun Aghilès, Van der Hauwaert Cynthia, Lopez Benjamin, Gibier Jean-Baptiste, Frimat Marie, Savary Grégoire, Hennart Benjamin, Larrue Romain, Pottier Nicolas, Broly Franck, Provôt François, Hazzan Marc, Glowacki François, Cauffiez Christelle

Abstract excerpt

Caveolin-1 is a protein (encoded by the CAV1 gene) supposedly harboring a protective effect against fibrosis. CAV1 rs4730751 single nucleotide polymorphism (SNP) AA genotype was initially associated with lower graft survival compared to non-AA. However, subsequent studies could not find the same effect. CAV1 rs4730751 SNP was investigated on 918 kidney donors. Multivariate Cox-model analyses were performed to...

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Identifiers

PMID: 31664124
DOI: 10.1038/s41598-019-52079-8
PMCID: PMC6820546

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