Article
The APOL1 gene and allograft survival after kidney transplantation.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons - 1 May 2011
Reeves-Daniel A M, DePalma J A, Bleyer A J, Rocco M V, Murea M, Adams P L, Langefeld C D, Bowden D W, Hicks P J, Stratta R J, Lin J-J, Kiger D F, Gautreaux M D, Divers J, Freedman B I
Abstract excerpt
Coding variants in the apolipoprotein L1 gene (APOL1) are strongly associated with nephropathy in African Americans (AAs). The effect of transplanting kidneys from AA donors with two APOL1 nephropathy risk variants is unknown. APOL1 risk variants were genotyped in 106 AA deceased organ donors and graft survival assessed in 136 resultant kidney transplants. Cox-proportional hazard models tested for association...
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