Article
Association of caveolin-1 gene polymorphism with kidney transplant fibrosis and allograft failure.
JAMA - 7 Apr 2010
Moore Jason, McKnight Amy Jayne, Simmonds Matthew J, Courtney Aisling E, Hanvesakul Rajesh, Brand Oliver J, Briggs David, Ball Simon, Cockwell Paul, Patterson Christopher C, Maxwell Alexander P, Gough Stephen C L, Borrows Richard
Abstract excerpt
CONTEXT: Caveolin-1 (CAV1) is an inhibitor of tissue fibrosis. OBJECTIVE: To study the association of CAV1 gene variation with kidney transplant outcome, using kidney transplantation as a model of accelerated fibrosis. DESIGN, SETTING, AND PATIENTS: Candidate gene association and validation study. Genomic DNA from 785 white kidney transplant donors and their respective recipients (transplantations in Birmingham,...
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