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Article

Comprehensive investigation of the caveolin 2 gene: resequencing and association for kidney transplant outcomes.

PloS one - 1 Jan 2013

McCaughan Jennifer A, Duffy Seamus, O'Hagan Thomas, Courtney Aisling E, Borrows Richard, Conlon Peter J, Maxwell Alexander P, McKnight Amy Jayne

Abstract excerpt

Caveolae are plasma membrane structures formed from a complex of the proteins caveolin-1 and caveolin-2. Caveolae interact with pro-inflammatory cytokines and are dysregulated in fibrotic disease. Although caveolae are present infrequently in healthy kidneys, they are abundant during kidney injury. An association has been identified between a CAV1 gene variant and long term kidney transplant survival. Chronic,...

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Source

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Identifiers

PMID: 23667606
DOI: 10.1371/journal.pone.0063358
PMCID: PMC3646761

Genes

CAV2
CAV1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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